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Stock","direction":"acquired","pricePerShare":"144.83","sharesOwnedAfter":"22220"}]},"basis":"external_source","via":["https://www.sec.gov/Archives/edgar/data/1110803/000111080326000118/form4.xml","https://www.sec.gov/ix?doc=/Archives/edgar/data/0001110803/000119312524087264/d534824ddef14a.htm"],"about_ref":"relationship:2932bc8d-45d9-469b-9a44-ccec5bff56da","source_surface_ref":"https://www.sec.gov"},{"label":"SIEGEL SUSAN E","value":{"asOf":"2026-05-21","form":"4","name":"SIEGEL SUSAN E","@type":"Person","roles":["director"],"holdings":[{"heldAs":"direct","shares":"16535","security":"Common Stock"},{"heldAs":"Reed-Siegel Revocable Trust","shares":"4006","security":"Common Stock"}],"insiderOf":{"name":"ILLUMINA, INC.","@type":"Organization"},"identifier":{"name":"SEC CIK","@type":"PropertyValue","value":"1240363"},"transactions":[{"code":"A","date":"2026-05-21","event":"grant or award","notes":["Grant of restricted stock units. 100% of the shares subject to the restricted stock unit award shall vest on the earlier of (i) the one year anniversary of the date of grant of the award and (ii) the date immediately preceding the date of the annual meeting of the company's stockholders for the year following the year of grant of the award, provided, in each case, that the awardee continues to serve as a director on such date."],"shares":"2072","security":"Common Stock","direction":"acquired","pricePerShare":"144.83","sharesOwnedAfter":"16535"}]},"basis":"external_source","via":["https://www.sec.gov/Archives/edgar/data/1110803/000111080326000120/form4.xml","https://www.sec.gov/ix?doc=/Archives/edgar/data/0001110803/000119312524087264/d534824ddef14a.htm"],"about_ref":"relationship:2932bc8d-45d9-469b-9a44-ccec5bff56da","source_surface_ref":"https://www.sec.gov"},{"label":"KING DAVID P","value":{"asOf":"2026-05-21","form":"4","name":"KING DAVID P","@type":"Person","roles":["director"],"holdings":[{"heldAs":"direct","shares":"2072","security":"Common Stock"}],"insiderOf":{"name":"ILLUMINA, INC.","@type":"Organization"},"identifier":{"name":"SEC CIK","@type":"PropertyValue","value":"1275654"},"transactions":[{"code":"A","date":"2026-05-21","event":"grant or award","notes":["Grant of restricted stock units. 100% of the shares subject to the restricted stock unit award shall vest on the earlier of (i) the one year anniversary of the date of grant of the award and (ii) the date immediately preceding the date of the annual meeting of the company's stockholders for the year following the year of grant of the award, provided, in each case, that the awardee continues to serve as a director on such date."],"shares":"2072","security":"Common Stock","direction":"acquired","pricePerShare":"144.83","sharesOwnedAfter":"2072"}]},"basis":"external_source","via":["https://www.sec.gov/Archives/edgar/data/1110803/000111080326000121/form4.xml","https://www.sec.gov/ix?doc=/Archives/edgar/data/0001110803/000119312524087264/d534824ddef14a.htm"],"about_ref":"relationship:2932bc8d-45d9-469b-9a44-ccec5bff56da","source_surface_ref":"https://www.sec.gov"},{"label":"Meister Keith A.","value":{"asOf":"2026-09-30","form":"4","name":"Meister Keith A.","@type":"Person","roles":["director"],"holdings":[{"heldAs":"direct","shares":"6887","security":"Common Stock"},{"heldAs":"See footnote","shares":"770350","security":"Common Stock"}],"insiderOf":{"name":"ILLUMINA, INC.","@type":"Organization"},"identifier":{"name":"SEC CIK","@type":"PropertyValue","value":"1307631"},"transactions":[{"code":"A","date":"2026-09-30","event":"grant or award","notes":["Mr. Meister elected to receive 100% of his 2026 board and committee cash retainer fees in Illumina stock. The number of shares issued in lieu of cash is based on the quotient of (i) the cash compensation otherwise payable for the immediately completed quarter divided by (ii) the volume weighted average closing price per share during the immediately completed quarter, calculated by reference to each trading day during such quarter. The amount reported on this Form represents Mr. Meister's 3rd quarter 2026 retainer fees."],"shares":"107","security":"Common Stock","direction":"acquired","pricePerShare":"219.8037","sharesOwnedAfter":"6887"},{"code":"S","date":"2026-09-04","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $218.00 to $218.99.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"100650","security":"Common Stock","direction":"disposed","pricePerShare":"218.39","sharesOwnedAfter":"781701"},{"code":"S","date":"2026-09-04","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $219.00 to $219.56.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"11351","security":"Common Stock","direction":"disposed","pricePerShare":"219.18","sharesOwnedAfter":"770350"},{"code":"S","date":"2026-09-04","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $217.00 to $217.84.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"7500","security":"Common Stock","direction":"disposed","pricePerShare":"217.28","sharesOwnedAfter":"882351"},{"code":"S","date":"2026-09-03","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $215.81 to $216.80.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"13261","security":"Common Stock","direction":"disposed","pricePerShare":"216.38","sharesOwnedAfter":"944102"},{"code":"S","date":"2026-09-03","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $218.88 to $219.87.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"13717","security":"Common Stock","direction":"disposed","pricePerShare":"219.41","sharesOwnedAfter":"906468"},{"code":"S","date":"2026-09-03","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $216.81 to $217.78.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"14196","security":"Common Stock","direction":"disposed","pricePerShare":"217.29","sharesOwnedAfter":"929906"},{"code":"S","date":"2026-09-03","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $219.88 to $220.85.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"6656","security":"Common Stock","direction":"disposed","pricePerShare":"220.17","sharesOwnedAfter":"899812"},{"code":"S","date":"2026-09-03","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $214.80 to $215.77.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"8439","security":"Common Stock","direction":"disposed","pricePerShare":"215.2","sharesOwnedAfter":"957363"},{"code":"S","date":"2026-09-03","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $217.86 to $218.85.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"9721","security":"Common Stock","direction":"disposed","pricePerShare":"218.33","sharesOwnedAfter":"920185"},{"code":"S","date":"2026-09-03","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $220.88 to $221.66.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"9961","security":"Common Stock","direction":"disposed","pricePerShare":"221.55","sharesOwnedAfter":"889851"},{"code":"S","date":"2026-09-02","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $213.42 to $214.02.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"10620","security":"Common Stock","direction":"disposed","pricePerShare":"213.73","sharesOwnedAfter":"965802"},{"code":"S","date":"2026-09-02","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $212.42 to $213.41. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (3)-(14) to this Form 4.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"57488","security":"Common Stock","direction":"disposed","pricePerShare":"213.2","sharesOwnedAfter":"976422"},{"code":"S","date":"2026-08-27","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $229.04 to $230.03.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"16990","security":"Common Stock","direction":"disposed","pricePerShare":"229.72","sharesOwnedAfter":"1071754"},{"code":"S","date":"2026-08-27","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $228.04 to $229.03.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"24363","security":"Common Stock","direction":"disposed","pricePerShare":"228.64","sharesOwnedAfter":"1088744"},{"code":"S","date":"2026-08-27","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $230.04 to $231.03.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"28439","security":"Common Stock","direction":"disposed","pricePerShare":"230.54","sharesOwnedAfter":"1043315"},{"code":"S","date":"2026-08-27","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $226.04 to $227.03.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"4873","security":"Common Stock","direction":"disposed","pricePerShare":"226.74","sharesOwnedAfter":"1167416"},{"code":"S","date":"2026-08-27","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $227.04 to $228.03.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"54309","security":"Common Stock","direction":"disposed","pricePerShare":"227.67","sharesOwnedAfter":"1113107"},{"code":"S","date":"2026-08-27","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $231.04 to $231.71.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"9405","security":"Common Stock","direction":"disposed","pricePerShare":"231.23","sharesOwnedAfter":"1033910"},{"code":"S","date":"2026-08-26","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $226.09 to $226.95.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"14782","security":"Common Stock","direction":"disposed","pricePerShare":"226.5","sharesOwnedAfter":"1172714"},{"code":"S","date":"2026-08-26","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $224.09 to $225.08.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"38213","security":"Common Stock","direction":"disposed","pricePerShare":"224.72","sharesOwnedAfter":"1240619"},{"code":"S","date":"2026-08-26","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $227.09 to $227.50.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"425","security":"Common Stock","direction":"disposed","pricePerShare":"227.22","sharesOwnedAfter":"1172289"},{"code":"S","date":"2026-08-26","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $225.09 to $226.08.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"53123","security":"Common Stock","direction":"disposed","pricePerShare":"225.69","sharesOwnedAfter":"1187496"},{"code":"S","date":"2026-08-25","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $225.77 to $226.75.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"38201","security":"Common Stock","direction":"disposed","pricePerShare":"226.13","sharesOwnedAfter":"1278874"},{"code":"S","date":"2026-08-25","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $226.78 to $226.80.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"42","security":"Common Stock","direction":"disposed","pricePerShare":"226.79","sharesOwnedAfter":"1278832"},{"code":"S","date":"2026-08-25","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $224.77 to $225.76. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (3)-(15) to this Form 4.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"92776","security":"Common Stock","direction":"disposed","pricePerShare":"225.26","sharesOwnedAfter":"1317075"},{"code":"S","date":"2026-08-21","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $216.07 to $217.06.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"12602","security":"Common Stock","direction":"disposed","pricePerShare":"216.44","sharesOwnedAfter":"1642002"},{"code":"S","date":"2026-08-21","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $212.06 to $213.05.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"13050","security":"Common Stock","direction":"disposed","pricePerShare":"212.65","sharesOwnedAfter":"1684458"},{"code":"S","date":"2026-08-21","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $219.07 to $220.06.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"133256","security":"Common Stock","direction":"disposed","pricePerShare":"219.47","sharesOwnedAfter":"1413734"},{"code":"S","date":"2026-08-21","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $214.07 to $215.06.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"13668","security":"Common Stock","direction":"disposed","pricePerShare":"214.64","sharesOwnedAfter":"1663969"},{"code":"S","date":"2026-08-21","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $220.07 to $220.43.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"3883","security":"Common Stock","direction":"disposed","pricePerShare":"220.13","sharesOwnedAfter":"1409851"},{"code":"S","date":"2026-08-21","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $210.01 to $210.99.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"4528","security":"Common Stock","direction":"disposed","pricePerShare":"210.45","sharesOwnedAfter":"1704659"},{"code":"S","date":"2026-08-21","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $213.07 to $214.06.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"6821","security":"Common Stock","direction":"disposed","pricePerShare":"213.81","sharesOwnedAfter":"1677637"},{"code":"S","date":"2026-08-21","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $211.06 to $212.04.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"7151","security":"Common Stock","direction":"disposed","pricePerShare":"211.54","sharesOwnedAfter":"1697508"},{"code":"S","date":"2026-08-21","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $217.07 to $218.05.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"8187","security":"Common Stock","direction":"disposed","pricePerShare":"217.84","sharesOwnedAfter":"1633815"},{"code":"S","date":"2026-08-21","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $218.07 to $219.06.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"86825","security":"Common Stock","direction":"disposed","pricePerShare":"218.6","sharesOwnedAfter":"1546990"},{"code":"S","date":"2026-08-21","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $215.07 to $216.06.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"9365","security":"Common Stock","direction":"disposed","pricePerShare":"215.61","sharesOwnedAfter":"1654604"},{"code":"S","date":"2026-08-20","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $207.01 to $207.91.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"1132","security":"Common Stock","direction":"disposed","pricePerShare":"207.65","sharesOwnedAfter":"1993293"},{"code":"S","date":"2026-08-20","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $216.14 to $217.13.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"15263","security":"Common Stock","direction":"disposed","pricePerShare":"216.88","sharesOwnedAfter":"1745375"},{"code":"S","date":"2026-08-20","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $215.14 to $216.13.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"18405","security":"Common Stock","direction":"disposed","pricePerShare":"215.62","sharesOwnedAfter":"1760638"},{"code":"S","date":"2026-08-20","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $217.14 to $218.13.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"21147","security":"Common Stock","direction":"disposed","pricePerShare":"217.72","sharesOwnedAfter":"1724228"},{"code":"S","date":"2026-08-20","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $210.11 to $211.09.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"23638","security":"Common Stock","direction":"disposed","pricePerShare":"210.66","sharesOwnedAfter":"1957014"},{"code":"S","date":"2026-08-20","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $212.14 to $213.12.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"29805","security":"Common Stock","direction":"disposed","pricePerShare":"212.83","sharesOwnedAfter":"1893200"},{"code":"S","date":"2026-08-20","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $211.14 to $212.13.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"34009","security":"Common Stock","direction":"disposed","pricePerShare":"211.9","sharesOwnedAfter":"1923005"},{"code":"S","date":"2026-08-20","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $208.02 to $209.01.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"3563","security":"Common Stock","direction":"disposed","pricePerShare":"208.55","sharesOwnedAfter":"1989730"},{"code":"S","date":"2026-08-20","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $214.14 to $215.11.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"42218","security":"Common Stock","direction":"disposed","pricePerShare":"214.57","sharesOwnedAfter":"1779043"},{"code":"S","date":"2026-08-20","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $218.14 to $219.13.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"5693","security":"Common Stock","direction":"disposed","pricePerShare":"218.46","sharesOwnedAfter":"1718535"},{"code":"S","date":"2026-08-20","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $213.14 to $214.13.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"71939","security":"Common Stock","direction":"disposed","pricePerShare":"213.36","sharesOwnedAfter":"1821261"},{"code":"S","date":"2026-08-20","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $209.11 to $210.10.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"9078","security":"Common Stock","direction":"disposed","pricePerShare":"209.68","sharesOwnedAfter":"1980652"},{"code":"S","date":"2026-08-20","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $219.15 to $220.00.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"9348","security":"Common Stock","direction":"disposed","pricePerShare":"219.82","sharesOwnedAfter":"1709187"},{"code":"S","date":"2026-08-19","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $204.72 to $205.11.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"12813","security":"Common Stock","direction":"disposed","pricePerShare":"205","sharesOwnedAfter":"1994425"},{"code":"S","date":"2026-08-19","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $201.59 to $202.58. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (3)-(30) to this Form 4.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"19884","security":"Common Stock","direction":"disposed","pricePerShare":"202.37","sharesOwnedAfter":"2069541"},{"code":"S","date":"2026-08-19","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $203.65 to $204.61.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"4759","security":"Common Stock","direction":"disposed","pricePerShare":"204.16","sharesOwnedAfter":"2007238"},{"code":"S","date":"2026-08-19","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $202.59 to $203.58.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"57544","security":"Common Stock","direction":"disposed","pricePerShare":"203.16","sharesOwnedAfter":"2011997"},{"code":"S","date":"2026-08-05","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $201.60 to $202.58.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"11372","security":"Common Stock","direction":"disposed","pricePerShare":"201.8","sharesOwnedAfter":"2091875"},{"code":"S","date":"2026-08-05","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $199.60 to $200.59.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"118753","security":"Common Stock","direction":"disposed","pricePerShare":"199.87","sharesOwnedAfter":"2133645"},{"code":"S","date":"2026-08-05","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $202.60 to $203.50.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"2450","security":"Common Stock","direction":"disposed","pricePerShare":"203.28","sharesOwnedAfter":"2089425"},{"code":"S","date":"2026-08-05","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $200.60 to $201.59.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"30398","security":"Common Stock","direction":"disposed","pricePerShare":"201.37","sharesOwnedAfter":"2103247"},{"code":"S","date":"2026-08-05","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $197.60 to $198.59.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"52249","security":"Common Stock","direction":"disposed","pricePerShare":"198.18","sharesOwnedAfter":"2320445"},{"code":"S","date":"2026-08-05","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $198.60 to $199.59.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"68047","security":"Common Stock","direction":"disposed","pricePerShare":"198.97","sharesOwnedAfter":"2252398"},{"code":"S","date":"2026-08-04","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $198.00 to $198.98.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"166501","security":"Common Stock","direction":"disposed","pricePerShare":"198.24","sharesOwnedAfter":"2628995"},{"code":"S","date":"2026-08-04","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $197.00 to $197.99.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"27854","security":"Common Stock","direction":"disposed","pricePerShare":"197.48","sharesOwnedAfter":"2795496"},{"code":"S","date":"2026-08-04","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $199.00 to $199.96.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"35160","security":"Common Stock","direction":"disposed","pricePerShare":"199.51","sharesOwnedAfter":"2593835"},{"code":"S","date":"2026-08-04","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $200.00 to $200.99.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"37242","security":"Common Stock","direction":"disposed","pricePerShare":"200.65","sharesOwnedAfter":"2556593"},{"code":"S","date":"2026-08-04","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $202.00 to $202.99.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"48186","security":"Common Stock","direction":"disposed","pricePerShare":"202.43","sharesOwnedAfter":"2440682"},{"code":"S","date":"2026-08-04","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $201.00 to $201.99.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"67725","security":"Common Stock","direction":"disposed","pricePerShare":"201.44","sharesOwnedAfter":"2488868"},{"code":"S","date":"2026-08-04","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $203.00 to $203.44.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"67988","security":"Common Stock","direction":"disposed","pricePerShare":"203.09","sharesOwnedAfter":"2372694"},{"code":"S","date":"2026-08-04","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $196.00 to $196.99. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (3) and (5) to (17) to this Form 4.","Our Section 16 filings inadvertently reported that the reporting person indirectly owned 100 fewer shares of common stock. The correct number of shares indirectly owned prior to the sales reported on this filing was 2,830,552 shares of common stock. The amount reported in Column 5 reflects such correction.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"7202","security":"Common Stock","direction":"disposed","pricePerShare":"196.74","sharesOwnedAfter":"2823350"},{"code":"A","date":"2026-06-30","event":"grant or award","notes":["Mr. Meister elected to receive 100% of his 2026 board and committee cash retainer fees in Illumina stock. The number of shares issued in lieu of cash is based on the quotient of (i) the cash compensation otherwise payable for the immediately completed quarter divided by (ii) the volume weighted average closing price per share during the immediately completed quarter, calculated by reference to each trading day during such quarter. The amount reported on this Form represents Mr. Meister's 2nd quarter 2026 retainer fees."],"shares":"142","security":"Common Stock","direction":"acquired","pricePerShare":"149.1868","sharesOwnedAfter":"6780"},{"code":"S","date":"2026-06-01","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $165.00 to $165.95.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"15472","security":"Common Stock","direction":"disposed","pricePerShare":"165.5","sharesOwnedAfter":"2830452"},{"code":"S","date":"2026-06-01","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $163.00 to $163.99.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"61613","security":"Common Stock","direction":"disposed","pricePerShare":"163.56","sharesOwnedAfter":"2933577"},{"code":"S","date":"2026-06-01","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $162.00 to $162.99.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"70262","security":"Common Stock","direction":"disposed","pricePerShare":"162.41","sharesOwnedAfter":"2995190"},{"code":"S","date":"2026-06-01","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $164.00 to $164.99.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"87653","security":"Common Stock","direction":"disposed","pricePerShare":"164.34","sharesOwnedAfter":"2845924"},{"code":"S","date":"2026-05-29","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $159.05 to $160.04.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"11760","security":"Common Stock","direction":"disposed","pricePerShare":"159.57","sharesOwnedAfter":"3268288"},{"code":"S","date":"2026-05-29","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $165.20 to $165.43.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"1961","security":"Common Stock","direction":"disposed","pricePerShare":"165.3","sharesOwnedAfter":"3065452"},{"code":"S","date":"2026-05-29","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $163.13 to $164.09.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"19832","security":"Common Stock","direction":"disposed","pricePerShare":"163.57","sharesOwnedAfter":"3236396"},{"code":"S","date":"2026-05-29","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $162.05 to $162.98.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"2225","security":"Common Stock","direction":"disposed","pricePerShare":"162.44","sharesOwnedAfter":"3256228"},{"code":"S","date":"2026-05-29","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $160.05 to $161.03.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"4579","security":"Common Stock","direction":"disposed","pricePerShare":"160.5","sharesOwnedAfter":"3263709"},{"code":"S","date":"2026-05-29","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $161.05 to $162.03.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"5256","security":"Common Stock","direction":"disposed","pricePerShare":"161.64","sharesOwnedAfter":"3258453"},{"code":"S","date":"2026-05-29","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $163.19 to $164.18.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"6198","security":"Common Stock","direction":"disposed","pricePerShare":"163.97","sharesOwnedAfter":"3160290"},{"code":"S","date":"2026-05-29","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $162.19 to $163.16.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"63020","security":"Common Stock","direction":"disposed","pricePerShare":"162.86","sharesOwnedAfter":"3166488"},{"code":"S","date":"2026-05-29","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $164.14 to $165.09.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"6888","security":"Common Stock","direction":"disposed","pricePerShare":"164.75","sharesOwnedAfter":"3229508"},{"code":"S","date":"2026-05-29","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $164.19 to $165.18.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"92877","security":"Common Stock","direction":"disposed","pricePerShare":"164.56","sharesOwnedAfter":"3067413"},{"code":"J","date":"2026-05-28","event":"other acquisition or disposition","notes":["These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"24562","security":"Common Stock","direction":"disposed","pricePerShare":"156.4","sharesOwnedAfter":"3500048"},{"code":"S","date":"2026-05-28","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $157.85 to $158.77.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"110424","security":"Common Stock","direction":"disposed","pricePerShare":"147.5","sharesOwnedAfter":"3280048"},{"code":"S","date":"2026-05-28","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $155.85 to $156.84. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (5)-(21) to this Form 4.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"37590","security":"Common Stock","direction":"disposed","pricePerShare":"156.5","sharesOwnedAfter":"3462458"},{"code":"S","date":"2026-05-28","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $156.85 to $157.84.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"71986","security":"Common Stock","direction":"disposed","pricePerShare":"157.38","sharesOwnedAfter":"3390472"},{"code":"X","date":"2026-05-28","event":"exercise of an in- or at-the-money derivative","notes":["These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"24562","security":"Common Stock","direction":"acquired","pricePerShare":"102.82","sharesOwnedAfter":"3524610"},{"code":"X","date":"2026-05-28","event":"exercise of an in- or at-the-money derivative","notes":["As previously reported, the Corvex Funds had entered into equity swaps that represented an aggregate economic long-side exposure comparable to a notional interest in 368,744 shares of common stock of the Issuer. Under the terms of the swaps, the value to be received or paid upon termination of a swap will be determined by the difference in the market price per notional share of common stock on the date of termination as compared to the cost of such notional share of common stock at the time of entry into the swap. On May 28, 2026, upon final termination of the swaps as reported in Table II above, the swaps counterparty paid to the Corvex Funds $3,841,496.80, representing $156.40 per share for each of the 24,562 notional shares subject to the termination (the market price of the common stock on the date of the partial termination), offset by $2,525,464.84, representing $102.82 for each of such 24,562 notional shares.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"24562","security":"Equity Swap (right to buy)","direction":"disposed","derivative":true,"exercisePrice":"102.82","expirationDate":"2028-02-11","sharesOwnedAfter":"0","underlyingShares":"24562","underlyingSecurity":"Common Stock"},{"code":"A","date":"2026-05-21","event":"grant or award","notes":["Grant of restricted stock units. 100% of the shares subject to the restricted stock unit award shall vest the date prior to the annual meeting of the company's stockholders in the year of the award, provided, in each case, that the awardee continues to serve as a director on such date."],"shares":"2072","security":"Common Stock","direction":"acquired","pricePerShare":"144.83","sharesOwnedAfter":"6638"},{"code":"S","date":"2026-05-14","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $143.50 to $144.49.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"12309","security":"Common Stock","direction":"disposed","pricePerShare":"144.13","sharesOwnedAfter":"3592132"},{"code":"S","date":"2026-05-14","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $146.50 to $147.49.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"13776","security":"Common Stock","direction":"disposed","pricePerShare":"146.96","sharesOwnedAfter":"3500228"},{"code":"S","date":"2026-05-14","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $147.50 to $148.06.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"180","security":"Common Stock","direction":"disposed","pricePerShare":"147.8","sharesOwnedAfter":"3500048"},{"code":"S","date":"2026-05-14","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $145.50 to $146.49.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"25352","security":"Common Stock","direction":"disposed","pricePerShare":"146.15","sharesOwnedAfter":"3514004"},{"code":"S","date":"2026-05-14","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $144.50 to $145.49.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"52776","security":"Common Stock","direction":"disposed","pricePerShare":"144.8","sharesOwnedAfter":"3539356"},{"code":"S","date":"2026-05-13","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $144.75 to $145.73. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (5)-(13) to this Form 4.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"159623","security":"Common Stock","direction":"disposed","pricePerShare":"145.26","sharesOwnedAfter":"3669885"},{"code":"S","date":"2026-05-13","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $148 to $148.49.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"5310","security":"Common Stock","direction":"disposed","pricePerShare":"148.14","sharesOwnedAfter":"3604441"},{"code":"S","date":"2026-05-13","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $145.75 to $146.74.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"53610","security":"Common Stock","direction":"disposed","pricePerShare":"145.94","sharesOwnedAfter":"3616275"},{"code":"S","date":"2026-05-13","event":"open-market or private sale","notes":["The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions within the range of $147 to $147.98.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"6524","security":"Common Stock","direction":"disposed","pricePerShare":"147.5","sharesOwnedAfter":"3609751"},{"code":"J","date":"2026-05-12","event":"other acquisition or disposition","notes":["These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"255378","security":"Common Stock","direction":"disposed","pricePerShare":"144.66","sharesOwnedAfter":"3829508"},{"code":"X","date":"2026-05-12","event":"exercise of an in- or at-the-money derivative","notes":["These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"255378","security":"Common Stock","direction":"acquired","pricePerShare":"102.82","sharesOwnedAfter":"4084886"},{"code":"X","date":"2026-05-12","event":"exercise of an in- or at-the-money derivative","notes":["As previously reported, the Corvex Funds had entered into equity swaps that represented an aggregate economic long-side exposure comparable to a notional interest in 368,744 shares of common stock of the Issuer. Under the terms of the swaps, the value to be received or paid upon termination of a swap will be determined by the difference in the market price per notional share of common stock on the date of termination as compared to the cost of such notional share of common stock at the time of entry into the swap. On May 12, 2026, upon partial termination of the swaps as reported in Table II above, the swaps counterparty paid to the Corvex Funds $36,942,981.48, representing $144.66 per share for each of the 255,378 notional shares subject to the termination (the market price of the common stock on the date of the partial termination), offset by $26,257,965.96, representing $102.82 for each of such 255,378 notional shares.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"255378","security":"Equity Swap (right to buy)","direction":"disposed","derivative":true,"exercisePrice":"102.82","expirationDate":"2028-02-11","sharesOwnedAfter":"24562","underlyingShares":"255378","underlyingSecurity":"Common Stock"},{"code":"J","date":"2026-05-11","event":"other acquisition or disposition","notes":["These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"79568","security":"Common Stock","direction":"disposed","pricePerShare":"143.45","sharesOwnedAfter":"3829508"},{"code":"X","date":"2026-05-11","event":"exercise of an in- or at-the-money derivative","notes":["These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"79568","security":"Common Stock","direction":"acquired","pricePerShare":"102.82","sharesOwnedAfter":"3909076"},{"code":"X","date":"2026-05-11","event":"exercise of an in- or at-the-money derivative","notes":["As previously reported, the Corvex Funds had entered into equity swaps that represented an aggregate economic long-side exposure comparable to a notional interest in 368,744 shares of common stock of the Issuer. Under the terms of the swaps, the value to be received or paid upon termination of a swap will be determined by the difference in the market price per notional share of common stock on the date of termination as compared to the cost of such notional share of common stock at the time of entry into the swap. On May 7, 2026, upon partial termination of the swaps as reported in Table II above, the swaps counterparty paid to the Corvex Funds $1,295,349, representing $140.25 per share for each of the 9,236 notional shares subject to the termination (the market price of the common stock on the date of the partial termination), offset by $949,645.52, representing $102.82 for each of such 9,236 notional shares.","In addition, on May 11, 2026, upon partial termination of the swaps as reported in Table II above, the swaps counterparty paid to the Corvex Funds $11,414,029.60, representing $143.45 per share for each of the 79,568 notional shares subject to the termination (the market price of the common stock on the date of the partial termination), offset by $8,181,181.76, representing $102.82 for each of such 79,568 notional shares.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"79568","security":"Equity Swap (right to buy)","direction":"disposed","derivative":true,"exercisePrice":"102.82","expirationDate":"2028-02-11","sharesOwnedAfter":"279940","underlyingShares":"79568","underlyingSecurity":"Common Stock"},{"code":"J","date":"2026-05-07","event":"other acquisition or disposition","notes":["These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"9236","security":"Common Stock","direction":"disposed","pricePerShare":"140.25","sharesOwnedAfter":"3829508"},{"code":"X","date":"2026-05-07","event":"exercise of an in- or at-the-money derivative","notes":["These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"9236","security":"Common Stock","direction":"acquired","pricePerShare":"102.82","sharesOwnedAfter":"3838744"},{"code":"X","date":"2026-05-07","event":"exercise of an in- or at-the-money derivative","notes":["As previously reported, the Corvex Funds had entered into equity swaps that represented an aggregate economic long-side exposure comparable to a notional interest in 368,744 shares of common stock of the Issuer. Under the terms of the swaps, the value to be received or paid upon termination of a swap will be determined by the difference in the market price per notional share of common stock on the date of termination as compared to the cost of such notional share of common stock at the time of entry into the swap. On May 7, 2026, upon partial termination of the swaps as reported in Table II above, the swaps counterparty paid to the Corvex Funds $1,295,349, representing $140.25 per share for each of the 9,236 notional shares subject to the termination (the market price of the common stock on the date of the partial termination), offset by $949,645.52, representing $102.82 for each of such 9,236 notional shares.","These securities of Illumina, Inc. (the \"Issuer\") are held for the accounts of certain private investment funds (collectively, the \"Corvex Funds\") for which Corvex Management LP (\"Corvex\") acts as investment adviser, including Corvex Master Fund LP and Corvex Select Equity Master Fund LP. The general partner of Corvex is controlled by Keith Meister.","For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise."],"shares":"9236","security":"Equity Swap (right to buy)","direction":"disposed","derivative":true,"exercisePrice":"102.82","expirationDate":"2028-02-11","sharesOwnedAfter":"359508","underlyingShares":"9236","underlyingSecurity":"Common Stock"},{"code":"A","date":"2026-03-31","event":"grant or award","notes":["Mr. Meister elected to receive 100% of his 2026 board and committee cash retainer fees in Illumina stock. The number of shares issued in lieu of cash is based on the quotient of (i) the cash compensation otherwise payable for the immediately completed quarter divided by (ii) the volume weighted average closing price per share during the immediately completed quarter, calculated by reference to each trading day during such quarter. 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